KMID : 0812020070130010021
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Korean Journal of Neurogastroenterology and Motility 2007 Volume.13 No. 1 p.21 ~ p.25
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Mucin Gene Expression and Cell proliferation in the Columnar Epithelium-Lined Mucosa of Distal Esophagus
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Choi Suck-Chei
Kim Yong-Sung Kim Ki-Hoon Kim Hun-Soo Jo Hyang-Jeong Yun Ki-Jung
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Abstract
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Background/Aims: Barrett¡¯s esophagus is characterized by the presence of metaplastic columnar epithelium with goblet cells in the distal esophagus. Barrett¡¯s esophagus progresses through low grade dysplasia and high grade dysplasia to adenocarcinoma. We studied the patient age, the mucin gene and the proliferation activity of biopsy-proven Barrett¡¯s esophagus and simple columnar epithelium-lined esophagus.
Methods: To evaluate the mucin gene expression and proliferation activity, twenty five cases of Barrett¡¯s esophagus and thirty cases of control esophagus were examined immunohistochemically with using the monoclonal antibodies to MUC1, MUC2 and Ki-67.
Results: The Barrett¡¯s esophagus patients were older (mean: 65.3+/-10.1 years) than the control patients (mean: 53.0+/-14.8 years). The MUC1 expression was 100% in both Barrett¡¯s esophagus and the control esophagus. An MUC2 expression was observed in 92.0% of the Barrett¡¯s esophagus and 20.0% of the control esophagus. The rate and intensity of the Ki-67 expression was higher in the Barrett¡¯s esophagus (80.0%, 1.20+/-0.76) than that in the control esophagus (70.0%, 0.77+/-0.57).
Conclusions: Barrett¡¯s esophagus is a metaplastic lesion due to the more long-standing gastroesophageal reflux than that in a simple columnar epithelium-lined esophagus. The cause of increased proliferation activity in Barrett¡¯s esophagus may be related to the MUC2 expression.
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KEYWORD
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Barrett`s esophagus, Age, MUC-1, MUC-2, Ki-67
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